Author: Rhys Gregory

A potential new treatment for schizophrenia developed by Cardiff University’s Medicines Discovery Institute has successfully completed the first phase (single ascending dose) of a Phase 1 clinical trial. The drug – MDI-26478 – is a positive allosteric modulator of the AMPA receptor, believed to play a key role in brain health. Cognitive decline is a core element of schizophrenia and current treatments fail to treat this effectively. The Cardiff team expects MDI-26478 to enhance cognitive performance, focused initially on schizophrenia. The drug has been invented by the MDI team and this study marks a major milestone, completing the ‘bench to…

A new grant scheme to help build cohesive and resilient communities has been launched. Community groups and third sector organisations across Cardiff are invited to apply for funding up to £2,000 to support schemes and initiatives that highlight and celebrate the diversity of communities across the city. Funding can be used for a range of purposes, including holding events and activities, producing supportive literature or building capacity within a community. Cabinet Member for Tackling Poverty, Equality and Public Health (Public Health & Equalities) Cllr Julie Sangani, said: “We’re looking for schemes that focus on bringing communities together and are encouraging…

Pembrokeshire County Council has closed Narberth Castle while safety checks are carried out. A Dangerous Structure report was filed with Building Control earlier this week after fallen stone work was found on the ground and inspection carried out. To protect the safety of pedestrians and members of the public the area has been closed temporarily. The level of repairs required will be established by the Local Authority Conservation Officer and Structural Engineer before the Castle is made safe and re-opened as soon as practically possible. Officers will consult with Cadw before any repairs commence. Head of Planning Nicola Gandy said:…

Residents are advised that resurfacing work will take place at Park Street, Treforest – scheduled on two Sundays (June 18 and 25) to minimise disruption. A road closure is required on both days of work, between Park Street’s junction with Castle Street to a point near the Premier Store. The work will take place in the daytime on both Sunday, June 18, and Sunday, June 25 – with the road closure in effect from 9am to 4pm on each day. An alternative route for motorists is available via Castle Street, Forest Road, Park Street, Llantwit Road, Tonteg Road, Upper Boat…

Wales’ national contemporary art collection will be displayed in communities across the country under new plans. Establishing a National Contemporary Art Gallery is a key commitment of the Welsh Government’s Programme for Government and the Co-operation Agreement with Plaid Cymru. The plans include: A network of galleries across Wales that will provide increased access to the national collection and bring contemporary art closer to communities. Host Galleries, Amgueddfa Cymru and National Library of Wales, will continue to hold and display Wales’ national art collection. An Anchor Gallery that will provide a prominent public face for the national contemporary art gallery.…

The headline NatWest Wales Business Activity Index – a seasonally adjusted index that measures the month-on-month change in the combined output of the region’s manufacturing and service sectors – registered 49.4 in May, down from 51.1 in April. The latest data signalled a renewed contraction in output, bringing to an end a three-month sequence of expansion. Of the 12 monitored UK areas, Welsh firms were alone in registering lower business activity. The decrease was only marginal overall, however. Companies noted that the fall was due to a slower rise in new orders. Welsh private sector firms recorded a third successive…

When it comes to oral health, most people focus on the aesthetic benefits of having straight teeth – but there is so much more to it than just an attractive smile! The alignment of your teeth plays a crucial role in various aspects of your general health, including how effectively you digest food. Intrigued? Let’s find out how getting straighter teeth can not only bring you a more confident smile but can also help you to improve your digestion into the bargain. Effective Chewing The process of digesting our food begins in our mouth. One of the main roles of…

You’ll note that nowadays, having a website is crucial for any business or individual attempting to establish an online presence. Web design Cardiff companies, such as Head45 Ltd, provide expert website design and development services to local companies wishing to build a solid online presence. They have the expertise and understanding required to create engaging and user-friendly websites that meet the specific requirements of their clients. Websites act as a company’s online front, giving it a platform to advertise its goods and services to a worldwide clientele. The creation and upkeep of these websites heavily rely on web designers and…

Dental implants have emerged as a popular and successful treatment option for replacing lost teeth and restoring dental function and aesthetics. Dental implants have a lot of advantages, but it’s crucial to be aware of any possible negative consequences that could develop during or after the implant process. For patients who are considering or having dental implant therapy, it is essential to comprehend these side effects and how to manage them. We will provide you with a thorough review of the typical and uncommon adverse effects of dental implants in this extensive guide, along with advice for risk management and…

The crypto market offers a multitude of entry opportunities, and determining the right ones can be a challenging task. There are various approaches to identify these opportunities, including following trends driven by news or market cycles, conducting fundamental analysis based on technology potential, and utilizing technical analysis tools. In this article, we will delve into each of these methods, showcasing the most effective tools and strategies for spotting entry points in the crypto market.  Trend Strategies for the Crypto Market It’s essential to understand that the crypto market operates in cycles characterized by alternating periods of bullish and bearish trends.…